Precigen (NASDAQ:PGEN – Get Free Report) and Biofrontera (NASDAQ:BFRI – Get Free Report) are both small-cap medical companies, but which is the better business? We will compare the two businesses based on the strength of their analyst recommendations, dividends, valuation, risk, profitability, institutional ownership and earnings.
Profitability
This table compares Precigen and Biofrontera’s net margins, return on equity and return on assets.
| Net Margins | Return on Equity | Return on Assets | |
| Precigen | -3,521.68% | -123.06% | -87.33% |
| Biofrontera | -36.31% | -565.73% | -96.64% |
Insider and Institutional Ownership
33.5% of Precigen shares are owned by institutional investors. Comparatively, 10.1% of Biofrontera shares are owned by institutional investors. 44.9% of Precigen shares are owned by company insiders. Comparatively, 0.2% of Biofrontera shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term.
Valuation and Earnings
| Gross Revenue | Price/Sales Ratio | Net Income | Earnings Per Share | Price/Earnings Ratio | |
| Precigen | $3.93 million | 100.02 | -$95.90 million | ($0.48) | -2.77 |
| Biofrontera | $37.32 million | 0.18 | -$20.13 million | ($2.26) | -0.31 |
Biofrontera has higher revenue and earnings than Precigen. Precigen is trading at a lower price-to-earnings ratio than Biofrontera, indicating that it is currently the more affordable of the two stocks.
Volatility and Risk
Precigen has a beta of 1.82, meaning that its share price is 82% more volatile than the S&P 500. Comparatively, Biofrontera has a beta of 0.37, meaning that its share price is 63% less volatile than the S&P 500.
Analyst Ratings
This is a summary of current ratings for Precigen and Biofrontera, as reported by MarketBeat.com.
| Sell Ratings | Hold Ratings | Buy Ratings | Strong Buy Ratings | Rating Score | |
| Precigen | 0 | 0 | 4 | 0 | 3.00 |
| Biofrontera | 0 | 0 | 1 | 0 | 3.00 |
Precigen presently has a consensus price target of $7.00, suggesting a potential upside of 426.32%. Biofrontera has a consensus price target of $7.00, suggesting a potential upside of 907.34%. Given Biofrontera’s higher possible upside, analysts clearly believe Biofrontera is more favorable than Precigen.
Summary
Precigen beats Biofrontera on 8 of the 13 factors compared between the two stocks.
About Precigen
Precigen, Inc. operates as a discovery and clinical-stage biopharmaceutical company that develops gene and cell therapies using precision technology to target diseases in therapeutic areas of immuno-oncology, autoimmune disorders, and infectious diseases. It operates through two segments, Biopharmaceuticals and Exemplar. The company offers therapeutic platforms consisting of UltraCAR-T to provide chimeric antigen receptor T cell therapies for cancer patients; AdenoVerse immunotherapy, which utilizes a library of proprietary adenovectors for gene delivery of therapeutic effectors, immunomodulators, and vaccine antigen; and ActoBiotics for specific disease modification. It also develops programs based on the UltraCAR-T platform, including PRGN-3005 in Phase 1b clinical trial to treat advanced ovarian, fallopian tube, or primary peritoneal cancer; PRGN-3006 in Phase 1b trial for patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndromes; and PRGN-3007 in Phase 1/1b trial for the treatment of advanced receptor tyrosine kinase-like orphan receptor 1-positive, hematologic, and solid tumors. In addition, the company is developing programs based on the AdenoVerse immunotherapy platform comprising PRGN-2009 in Phase 2 trial for patients with HPV-associated cancer; and PRGN-2012 in Phase ½ trial to treat recurrent respiratory papillomatosis, as well as AG019, which is based on the ActoBiotics platform and in Phase 1b/2a trial, to treat type 1 diabetes mellitus. Further, it provides UltraPorator, a proprietary electroporation device; and develops research models and services for healthcare research applications. The company was formerly known as Intrexon Corporation and changed its name to Precigen, Inc. in February 2020. Precigen, Inc. was founded in 1998 and is headquartered in Germantown, Maryland.
About Biofrontera
Biofrontera Inc., a biopharmaceutical company, engages in the commercialization of pharmaceutical products for the treatment of dermatological conditions in the United States. The company's products are used for the treatment of actinic keratoses, which are pre-cancerous skin lesions, as well as impetigo, a bacterial skin infection. It offers Ameluz, a prescription drug for use in combination with the RhodoLED lamp series, for photodynamic therapy for the lesion-directed and field-directed treatment of actinic keratosis of mild-to-moderate severity on the face and scalp. The company also provides Xepi, a topical non-fluorinated quinolone that inhibits bacterial growth for the treatment of impetigo. The company was incorporated in 2015 and is headquartered in Woburn, Massachusetts.
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